Lega Serie A has released the full match calendar for the upcoming 2023/24 campaign. In addition to the Champions League Group Stage, Napoli will commence the Coppa Italia in the Round of 16 on one of the following date: December 6 or 20, 2023, January 10 or 17, 2024).
| Round | Date | Home | Away |
| 1 | August 18-21, 2023 | Frosinone | Napoli |
| 2 | August 25-28, 2023 | Napoli | Sassuolo |
| 3 | September 1-4, 2023 | Napoli | Lazio |
| 4 | September 15-18, 2023 | Genoa | Napoli |
| UCL MD1 | September 19-20, 2023 | TBD | TBD |
| 5 | September 22-25, 2023 | Bologna | Napoli |
| 6 | September 26-28, 2023 (midweek) | Napoli | Udinese |
| 7 | September 29-October 2, 2023 | Lecce | Napoli |
| UCL MD2 | October 3-4, 2023 | TBD | TBD |
| 8 | October 6-9, 2023 | Napoli | Fiorentina |
| 9 | October 20-23, 2023 | Hellas Verona | Napoli |
| UCL MD3 | October 24-25, 2023 | TBD | TBD |
| 10 | October 27-30, 2023 | Napoli | Milan |
| 11 | November 3-6, 2023 | Salernitana | Napoli |
| UCL MD4 | November 7-8, 2023 | TBD | TBD |
| 12 | November 9-12, 2023 | Napoli | Empoli |
| 13 | November 24-27, 2023 | Atalanta | Napoli |
| UCL MD5 | November 28-29, 2023 | TBD | TBD |
| 14 | December 1-4, 2023 | Napoli | Inter |
| 15 | December 8-11, 2023 | Juventus | Napoli |
| UCL MD6 | December 12-13, 2023 | TBD | TBD |
| 16 | December 15-18, 2023 | Napoli | Cagliari |
| 17 | December 21-24, 2023 | Roma | Napoli |
| 18 | December 28-31, 2023 | Napoli | Monza |
| 19 | January 5-8, 2024 | Torino | Napoli |
| 20 | January 12-15, 2024 | Napoli | Salernitana |
| 21 | January 19-22, 2024 | Sassuolo | Napoli |
| 22 | January 26-29, 2024 | Lazio | Napoli |
| 23 | February 2-5, 2024 | Napoli | Hellas Verona |
| 24 | February 9-12, 2024 | Milan | Napoli |
| 25 | February 16-19, 2024 | Napoli | Genoa |
| 26 | February 23-26, 2024 | Cagliari | Napoli |
| 27 | March 1-4, 2024 | Napoli | Juventus |
| 28 | March 8-11, 2024 | Napoli | Torino |
| 29 | March 15-18, 2024 | Inter | Napoli |
| 30 | March 28-31, 2024 | Napoli | Atalanta |
| 31 | April 5-8, 2024 | Monza | Napoli |
| 32 | April 12-15, 2024 | Napoli | Frosinone |
| 33 | April 19-22, 2024 | Empoli | Napoli |
| 34 | April 26-29, 2024 | Napoli | Roma |
| 35 | May 3-6, 2024 | Udinese | Napoli |
| 36 | May 10-13, 2024 | Napoli | Bologna |
| 37 | May 17-20, 2024 | Fiorentina | Napoli |
| 38 | May 24-27, 2024 | Napoli | Lecce |
